Rilmazafone Hydrochloride

Description

Order Rilmazafone Hydrochloride

Description

Rilmazafone is a new hypnotic with anxiolytic properties. The major advantages of rilmazafone are claimed to be a significant reduction of motor ataxia and the lack of habituation or hang-over associated with other hypnotics. Order Rilmazafone Hydrochloride

When the animals are pretreated with high doses of Rilmazafone hydrochloride (450191-S; 200 or 600 mg/kg for 5 or 3 days, respectively) to induce hepatic drug-metabolizing enzymes, plasma concentrations of the metabolites after oral administration of a dose of 200 mg/kg of Rilmazafone decrease markedly depending on the induced enzyme activity.  Order Rilmazafone Hydrochloride

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Pretreatment of rats with phenobarbital also causes decreased plasma levels of metabolites, which are almost the same as those in Rilmazafone-pretreatment.

On the other hand, administration of beta-naphthoflavone to rats leads to higher plasma levels of metabolites, and slower elimination compared with those in the control and Rilmazafone or Phenobarbital pretreated rats.

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Rilmazafone is demonstrated to stimulate the hepatic drug-metabolizing enzymes in rats, mice and dogs, which is accompanied by a marked reduction in the pharmacological activity of pentobarbital in rats.

The induction of hepatic enzyme activities by Rilmazafone is detected only when the plasma concentrations of its metabolites are very high

Originator

Shionogi (Japan)

Uses

Rilmazafone Hydrochloride can be used in biological study of nitrazepam or rilmazafone hydrochloride combined with ethanol effects on human memory. It is also used as sleep aid medication.

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